Amino acid compositions of coral skeletons from 4 massive Porites spp. genotypes (G4, G5, G6, G7) cultured in an aquarium at seawater pCO2 of 180, 260, 400 and 750 µatm and at seawater temperature of 25 and 28°C. Protein was extracted from the skeletal samples and hydrolysed to individual amino acids. Data were collected to determine how environmental conditions influence coral skeletal biomolecules. Data were collected between August 2020 and December 2022 by Celeste Kellock, Cristina Castillo Alvarez, David Evans and Nicola Allison and interpreted by Celeste Kellock, Cristina Castillo Alvarez, David Evans, Nicola Allison, Adrian Finch, Kirsty Penkman, Roland Kröger, and Matthieu Clog.